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Design Expert User Group Meeting

 

You are invited to attend the 7th European DOE User Meeting this June. Held only every two years, this is a great opportunity for "Design-Expert" software users in Europe and beyond to gather together for an informative and fun event! The two-day meeting on the 7–8 June includes both invited speakers who are DOE experts, and practical case study presentations by actual Design-Expert users. You also won’t want to miss our special conference evening event on 7 June when we take a dinner cruise on the River Seine in beautiful Paris! 

The invited lectures will cover a broad spectrum of topics ranging from technical matters and the latest features in Design-Expert software to general DOE topics of current interest. Case study presentations will be presented by practitioners from a variety of industries. You’ll have the opportunity to network with other software users and get help from DOE consultants on your own particular situation.

On 6 June, there is an optional pre-conference workshop on Practical DOE “Tricks of the Trade”  by two of Stat-Ease’s founding principals, Pat Whitcomb and Mark Anderson. 

This year the conference will be held at Le CNAM, Paris from 6th to 8th June, 2018 and is being organized with the support of both Stat-Ease, Inc. and Ritme.

 

To register online click on the green button below (If you have any issues registering, please contact this email, or call +33 (0)1 42 46 00 42:

Register Online

 

PROGRAM:

Conference

The conference will include an optional pre-conference workshop on 6 June, followed by the 2-day user meeting on 7–8 June with talks by DOE Experts and industry practitioners. There will also be a special evening event on the 7th that includes a dinner cruise on the River Seine in beautiful Paris.

The program of the user meeting will cover a variety of topics from technical matters to the latest features in Design-Expert software to general DOE topics of interest. Check back for more details.

SCHEDULE 

Click on the link below to download the schedule

7th European DoE User Meeting Schedule

 

Speakers

Who are they ?

WHat are they talking about ?

 

Mark Anderson

Principal, Stat-Ease, Inc.

Using Graphics to Tell and Sell Your DOE Success Story (Keynote, day 1)

By way of a variety of case studies, Mark will present compelling visuals from Design-Expert® software version 11 (DX11) that make it easy to see, even for non-technical clients and managers, the highlights from design of experiments (DOE).  

 

Pat Whitcomb

Founding Principal, Stat-Ease, Inc

Exciting New Features in Design-Expert®—V11 and Beyond (Keynote, day 2)

Pat welcomes you to version 11 of Design-Expert® software (DX11). He presents his favorite new features and provides a ‘heads-up’ on what's in it for you

 

Maria Pia D’Ambrosio

SixSigmain Team snc., Design-Expert Senior Trainer & DOE Specialist,

Post DOE Robust Simulation. Topics, Techniques and Tools

A post-DoE technique, which would give further added value to DoE, is the Monte Carlo simulation that uses the obtained models, with the target to better manage the solutions in a long-term industrial process.

Paul Nelson

PhD, Technical Director, Prism Training & Consulting, Ltd. 

Practical (Real-life) Implementation of Definitive Screening Designs 

Custom Designs in Design-Expert® implement the idea of model-oriented design. That is, they maximise the information about a specified model. This suggests the analysis of designed experiments profits by taking advantage of what is already known about their structure: design-oriented modelling.

Philippe Pages

 

Independent Consultant & Trainer, PhP Stats

How to Evaluate the Quality of an Evolving Design? 

Several saturated designs in 22 runs do exist: Min-Run Characterize (Design Expert), Rechtschaffner matrix (literature)… 22 being not a power of two they cannot be perfectly orthogonal. Which is the best? In addition, initially planned factor levels cannot always be respected. What is the impact of those variations on the design quality?

Dimitris Alexandrakis

Business Development Director CAMO Software AS

Design of Experiments and Multivariate Analysis - a symbiotic partnership

The presentation will show various approaches to analyse data and visualise results from experimental designs in the case of multiple responses. An example with observed variables as covariates for a multivariate alternative MANCOVA will also be discussed.

 

B. Thomas Carr 

Principal, Carr Consulting

 

Modeling Sweet-Taste Synergy in Blends of High Potency Sweeteners Using Mixture Design 

Synergy has substantial economic impact for manufacturers who use high potency sweeteners in their products. Identifying the ratio of sweeteners that maximize sweet-taste synergy offers substantial cost savings opportunities. A three-component mixture experiment was developed using "Design-Expert" to determine the proportions of Aspartame, Acesulfame-K, and Neotame that maximize sweet-taste synergy.

 

David Brian Nicolaides 

Solutions Consultant, Dassualt Systemes BIOVIA

 Better Management of Computer Experiments Using Design-Expert

We discuss a particular application in the domain of chemical reactions, where we want to minimize the reaction byproducts by understanding and optimizing the reaction kinetics (which are notoriously difficult to measure). Design Expert together with Modelica, an open-source dynamic simulation toolkit, has been used to find the optimum reaction parameters, with quantifiable benefits for the reaction yield.

 

Francesco Tinazzi

Senior Scientist, Aptuit Verona

Use of DOE to Increase Process Understanding of a De-Bromination Reaction

The presentation describes the use of DoE to optimize and increase the process understanding of a de-bromination reaction via catalytic transfer hydrogenation (CTH), a key step in the synthesis of a potential drug, using formic acid as hydrogen donor and 5% palladium on charcoal as catalyst.

Daniel Tray

Scientific Investigator, API Chemistry, GSK

The Role of Fractional and D-Optimal Designs in the Development of a QbD Pharmaceutical Production Process: A Process Chemistry Case Study 

This talk will exemplify how DoEs created by "Design-Expert" software have been used to explore multiple unit operations of a complex chemical process and deliver the understanding necessary to comply with the requirements of a Quality-by-Design environment. These DoEs encompassed both traditional fractional factorial designs as well as resource efficient non-orthogonal D-Optimal designs. The challenges associated with analysing a sparse data set will be discussed and model selection strategies will be presented.

Christos Georgakis

Professor, Tufts University & Process Cybernetics LLC

 

DoDE & DRSM: Two Generalizations of the DoE and RSM Methodologies

This talk presents two generalizations Design of Dynamic Experiments (DoDE) and Dynamic Response Surface Methodology (DRSM). The first, DoDE, enables the design of experiments with time-varying inputs something that can be easily achieved with Design Expert. The Second one (DRSM) enables the development of RSM-type models when process measurements are available at several time instants during the experiment

 

Samd Guizani

Process Scientist, Ferring Pharmaceuticals

Transferring a Drug Product Formulation Design Space from Development to Production—Some Hurdles with DOE Application

Extended release (ER) formulations, and particularly granules, are commonly used as drug products. They have the advantage of releasing the Active Pharmaceutical Ingredient (API) over a long period providing the patient with a long-lasting therapeutic effect.

Johannes Felix Buyel

Head of Department, Fraunhofer IME

Design of Experiments Facilitate Optimization in Biopharmaceutical Protein Screening—a Case Sudy

In order to identify highly potent, safe and affordable biopharmaceuticals, an immense screening effort is required. We have therefore used a design of experiments (DoE) approach to identify the most relevant factors and to select conditions facilitating reproducible outcomes which is a prerequisite to use the system for subsequent high-throughput screening applications.

  Tim Revett

Science lead in Cell Culture Development at  Lonza Biologics

Design of experiment in Cell Culture Development and Process Development Sciences

A custom I-optimal response surface model was used to evaluate the effects of six factors in the process, with the aim to reduce the concentration of the increased metabolite,  whilst maintaining a high culture viability and productivity.  A high through-put, miniature bioreactor system was used to evaluate the model and generated a set of optimised conditions that met these requirements.

Markus Höfer

Dr. Markus Höfer
Fraunhofer Institute for Surface Engineering and Thin Films IST 

Development and Optimization of highly transparent SiO2 films 

The challenge was to find process parameters offering the opportunity to apply sufficiently high
amounts of oxygen, in order to make the SiO2 films completely stoichiometric, without
significant evaporation of tungsten oxides from the wires. By using DOE we succeeded, for the
first time ever, to develop a stable HWCVD process for preparing highly transparent SiO2 films
with almost no tungsten contaminants.

Pat Thomas

BS in Chemical Engineering and MBA from the University of Iowa  

New Peel Seal System for Flexible Medical Device Packaging Applications

A newly developed uncoated nylon reinforced paper provides an alternative to materials traditionally used for lidding. This paper serves to demonstrate the successful use of a Mixture DOE in the development of a new peel/seal system.  

Ashraf Zin

Senior scientist with PETRONAS

A statistical based study employing Response Surface Method (RSM) was conducted to ascertain the optimum lignocellulosic pretreatment conditions i.e. at different temperature, time and base concentration with Malaysian oil palm empty fruit bunches (EFB) was used as a model substrate.


Workshop

Practical DOE “Tricks of the Trade” by Pat Whitcomb and Mark Anderson

In this dynamic short-course, Stat-Ease Consultants Pat Whitcomb and Mark Anderson reveal tricks of their trade, made possible via Design-Expert® software, that make the most from statistical design and analysis of experiments. Come and learn many secrets for design-of-experiment (DOE) success, such as:

  • A four-step process for planning your experiment—taking power into consideration,
  • How to build irregularly shaped DOE spaces that cover your region of interest,
  • Clever tweaks to numerical optimization, and
  • Cool tools for augmenting a completed experiment to capture a peak beyond its reach.


Don’t miss this chance to sharpen up your DOE skills!

Workshop Outline


Conference dinner

The special evening event on the 7th will be a dinner cruise on the River Seine! Enjoy the magical atmosphere of Paris aboard an all-glass boat for a unique view of this romantic city.

People who register for the conference dinner will enjoy a prepared menu of creative French flavors, as well as a live jazz band while they chat and view Paris by night.

This cruise will start at 8 pm and will end at 11 pm.

 

 

REGISTRATIONS PACKS:

Register Online

To register online click on the green button below (If you have any issues registering, please contact this email, or call +33 (0)1 42 46 00 42:

  PACKS DURATION PRICE (before VAT)

PUBLIC

 DOE User Meeting (including evening event) 2 days 600€
Workshop “ Practical DOE “Tricks of the Trade” 
1 day 400€
DOE User Meeting (including evening event) + workshop
3 days 1000€

ACADEMIC

DOE User Meeting (including evening event) 2 days 420€
Workshop “ Practical DOE “Tricks of the Trade” ” 1 day 280€
DOE User Meeting (including evening event) + workshop 3 days 700€

 

To register online click on the green button below (If you have any issues registering, please contact this email, or call +33 (0)1 42 46 00 42:

Register Online

 

TRAVEL INFORMATION:

Nearby hotels:

Jules & Jim

Hôtel du Haut Marais

La Chambre du Marais

Hôtel Georgette

Hôtel Molay

Hôtel Le Marais (HappyCulture)

Hôtel des Arts et Métiers

Paris Tourist Information

Paris Convention and Visitors Bureau Website

 

Hopefully you can join us for the 7th European DOE User Meeting in 2018.

Look for more details to come!

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